Scientist (Mouse Genetics and Outsourced Breeding Management)
Description du poste
Scientist (Mouse Genetics and Outsourced Breeding Management)
Job description:
About the customer:
Start: ASAP (latest 01.04.2026)
Duration: 12 months, potential extension
Workload: 100%
Location: Basel
Team Size: 10
Requirements:
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Provide scientific and operational oversight of external CROs and internal breeding facilities to ensure high-quality delivery and compliance.
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Develop and implement optimized breeding strategies focusing on genetic stability, cost efficiency and timelines while aligning with 3R principles (Replacement, Reduction, Refinement).
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Act as primary contact for external vivarium partners and manage vendor relationships.
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Troubleshoot phenotype drift, health status deviations and breeding challenges.
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Serve as internal subject matter expert for the generation of new transgenic mouse lines using advanced genetic technologies.
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Define and standardize official nomenclature for newly generated lines in line with MGI and international guidelines.
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Maintain and review genotype documentation and molecular validation data such as NGS, Southern Blot and qPCR.
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Monitor welfare of experimental cohorts and define humane endpoints.
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Assess unexpected phenotypes in newly generated lines.
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Establish and implement housing and care standards for outsourced breeding partners.
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Collaborate closely with therapeutic area scientists to support early phenotypic characterization and validation of model utility.
Competences:
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PhD in Genetics, Molecular Biology, Biotechnology or a related discipline.
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Minimum 3 years of hands-on experience in mouse genetics and colony management.
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Proven track record in generating and validating transgenic mouse models.
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Strong knowledge of breeding strategies and colony optimization aligned with 3R principles.
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Familiarity with FELASA guidelines and animal welfare legislation.
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Experience managing external vendors or CRO relationships.
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Solid understanding of molecular validation techniques including NGS, qPCR and Southern Blot.
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Fluent English required. German is a plus.
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